Three investigator-led, retrospective case series evaluating the long-term effectiveness of canaloplasty using the Itrack device (Nova Eye Medical) in patients with open-angle glaucoma have been published, the company announced. A 36-month case series in Ophthalmology Glaucoma and a 48-month case series in Klinische Monatsblätter für Augenheilkunde both demonstrated a significant reduction in mean IOP as compared to baseline, along with a significant decrease in the mean number of glaucoma medications, following Itrack canaloplasty.^1,2

A total of 44 eyes of 44 patients were included in the first study; 23 eyes underwent Itrack as a standalone procedure and 21 eyes had Itrack in combination with cataract surgery. A statistically significant reduction in IOP and number of medications between baseline and all postoperative visits (P<.0001) either when canaloplasty was performed as a standalone procedure or in combination with cataract surgery was found. The second study confirmed the first, with the comparable reduction in IOP and medications sustained at 48 months postoperatively.

A third case series report, published in Cornea, found that canaloplasty was effective and safe in 17 eyes after corneal transplant.³ The authors found that canaloplasty effectively reduced IOP and maintained graft survivability in postkeratoplasty eyes for at least 12 months. Nova Eye Medical reported in a news release that the frequency of surgical and postsurgical complications reported was low in all 3 studies, with no serious adverse events recorded.

References

1. Gallardo MJ. 36-month effectiveness of ab interno canaloplasty standalone vs combined with cataract surgery for the treatment of open-angle glaucoma [published online ahead of print, 2022 Feb 17]. Ophthalmol Glaucoma. 2022;S2589-4196(22)00025-4. doi:10.1016/j.ogla.2022.02.007
2. Koerber N, Ondrejka S. Four-year efficacy and safety of iTrack ab interno canaloplasty as a standalone procedure and combined with cataract surgery in open-angle glaucoma [published online ahead of print, 2022 Apr 14]. Klin Monbl Augenheilkd. 2022;10.1055/a-1737-4149. doi:10.1055/a-1737-4149
3. Riaz K, Gill MS, Murphy DA, Ding K, Khaimi MA. Surgical management of intraocular pressure with ab interno canaloplasty in postkeratoplasty patients: 12-month results [published online ahead of print 2022 March 5]. Cornea. 2022. doi:10.1097/ICO.0000000000003009