Video: Preservative-Free Bimatoprost Gel Represents a New Approach

At the Glaucoma Innovation Summit, Eydie Miller-Ellis, MD, discussed how this next-generation bimatoprost formulation lowers IOP while minimizing ocular surface irritation.

By: Eydie Miller-Ellis, MD,

Glaucoma Physician March 6, 2026

5 Key Takeaways

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Preservative-free bimatoprost 0.01% gel, marketed as Zolymbus, aims to lower intraocular pressure (IOP) while minimizing ocular surface irritation.
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The gel formulation utilizes mucoadhesive properties to enhance drug absorption and maintain contact with the cornea.
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This new formulation avoids benzalkonium chloride (BAK), which is known to irritate the ocular surface in glaucoma patients.
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Pharmacokinetic studies show that the preservative-free gel achieves intraocular concentrations comparable to bimatoprost 0.03%.
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Zolymbus is expected to be available in the US market by the end of 2026, enhancing glaucoma treatment options.

Eydie G. Miller-Ellis

Director of Glaucoma

Affiliations: University of Pennsylvania Scheie Eye Institute

Specialties: Glaucoma

Bio: Eydie G. Miller-Ellis, MD, is director of glaucoma at the University of Pennsylvania Scheie Eye Institute. Her clinical focus includes glaucoma therapy, intraocular pressure reduction, and approaches that minimize ocular surface irritation in patients requiring topical treatment. At the American Glaucoma Society Innovation Summit, Dr. Miller-Ellis discussed preservative-free bimatoprost 0.01% gel, including pharmacokinetic findings and the rationale for a mucoadhesive formulation designed to support corneal contact time while avoiding benzalkonium chloride exposure.

Eydie Miller-Ellis, MD

Specialties: Retina

Bio: Eydie Miller-Ellis, MD, is a physician author in the retina field. She contributed to a Retinal Physician article on improving diversity in retina, addressing racial and ethnic disparities in ophthalmology and the need to expand representation within retina training and practice.

PentaVision

Glaucoma Physician

Video: Preservative-Free Bimatoprost Gel Represents a New Approach

5 Key Takeaways

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