Researchers at Seoul National University College of Medicine in Seoul, Republic of Korea, tracked 131 patients with highly myopic open-angle glaucoma (OAG) for an average of 11.6 years, exploring the relationship between IOP reduction and disease progression. Patients were divided into groups based on IOP reduction, with those in the highest tertile, who achieved more than a 23.7% reduction, showing significantly lower rates of glaucoma progression compared to those with reductions below 11.0% (P=0.034), according to Kaplan-Meier analysis.

Disc hemorrhage (DH) emerged as a major risk factor, with a hazard ratio of 2.189 (P=0.032). For patients who experienced progression, the rate of retinal nerve fiber layer thinning was -0.88 µm per year, and the mean deviation in vision decreased by -0.42 dB per year. The data was published in the British Journal of Ophthalmology.