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Glaucoma Physician

Article | 2026 American Glaucoma Society Meeting

Xen Study Finds Ab Interno and Externo Approaches Equally Effective

Researchers from the University of Illinois College of Medicine found that both approaches reduce IOP, lower medications, and improve visual acuity.

By: Evan Lagouros, MD, Cecilia Canizela, BS
Glaucoma Physician February 23, 2026

Clinical Scorecard: Xen Study Finds Ab Interno and Externo Approaches Equally Effective

At a Glance

CategoryDetail
ConditionGlaucoma
Key MechanismsReduction of intraocular pressure (IOP) and improvement in visual acuity through surgical intervention.
Target PopulationPatients with glaucoma requiring surgical intervention to manage IOP.
Care SettingOphthalmology clinics and surgical centers.

Key Highlights

  • Both ab interno and ab externo approaches effectively reduce IOP.
  • Both methods lower the number of medications required.
  • Equivalent improvement in best-corrected visual acuity (BCVA) observed.
  • Study followed patients for up to 3 years.
  • No statistically significant difference between the two approaches at any time point.

Guideline-Based Recommendations

Diagnosis

  • Assess IOP and visual acuity in patients with glaucoma.

Management

  • Consider both ab interno and ab externo approaches for surgical intervention.

Monitoring & Follow-up

  • Regular follow-up for IOP and visual acuity post-surgery.

Risks

  • Potential surgical risks associated with both approaches.

Patient & Prescribing Data

Patients with glaucoma requiring surgical intervention.

Both surgical approaches are effective and can be chosen based on surgeon preference.

Clinical Best Practices

  • Evaluate patient-specific factors when choosing surgical approach.
  • Ensure thorough preoperative assessment of IOP and visual acuity.
  • Maintain regular postoperative monitoring for optimal outcomes.

References